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What is an extended-release Ambien pill? Extended-release Ambien pills are a type of medication that is designed to release the drug over a period of time. This type of pill works by releasing the Ambien into the bloodstream over a period of 12 to 24 hours, which allows for a longer period of sleep. Extended-release Ambien pills are usually taken as a tablet that is either swallowed whole or chewed and then swallowed.