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How does Adderall work for ADHD? The medication is a combination of amphetamine salts that act on the parts of the brain and control hyperactivity. In people with ADHD, Adderall reduces hyperactivity and inattentiveness by enhancing the effects of neurotransmitters. Dopamine and norepinephrine are chemicals in your brain that the medicine alters. Adderall is a medication for ADHD intended to improve hyperactivity, impulsive behavior, and attention span.