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What is Fioricet? Fioricet is a brand name for the Butalbital-Acetaminophen medication, an analgesic that is used to relieve tension-related pain. Its formula contains Acetaminophen (325 mg), butalbital (a barbiturate, 50 mg), and caffeine (40 mg). The FDA has advised the manufacturers to reduce the dosage of Acetaminophen to 300mg.