Looking to optimize your well-being, improve your healthspan, and extend your longevity? One of the perks of being a Tally Health member is a monthly subscription to our daily science-backed longevity supplement, Vitality. Our team of scientists studied thousands of research papers to create a potent combination of the most effective and bioavailable longevity-supporting ingredients, selected based on clinical studies on safety and efficacy. Vitality is one of the best ways to invest in your long-term health.

1 supplement to target all 12 hallmarks of aging

Why do we age? Biochemical processes known as the “hallmarks” of aging occur as we get older and leave us susceptible to age-related dysfunction, disease, and death. By targeting the 12 hallmarks of aging with a healthy lifestyle and supplementation, we make it easier to live healthier, longer. Vitality was designed to help slow aging by: 

• Inducing autophagy, a natural cellular process that recycles old and damaged cells. 
• Increasing NAD+ levels.   
• Activating sirtuin proteins that regulate cellular and metabolic processes. 
• Removing senescent or “zombie” cells.

Vitality: What’s inside?

At Tally Health, we believe that true vitality goes beyond basic wellness. Vitality contains 5 key natural ingredients in doses exponentially higher than what could be achieved with a healthy diet alone. Here’s what’s inside a daily dose (4 capsules) of our unique formulation:

Calcium alpha-ketoglutarate 
(Ca-AKG) 1000 mg

• Extended lifespan of mice by 12% on average 
• Boosts energy and mitochondrial function 
• Suppresses chronic inflammation (“inflammaging”) 
• Protects against age-related bone loss 
• Slows hair graying in mice 
• Inhibits mTOR and activates AMPK to support a healthy metabolism

Fisetin 100 mg

• Extends lifespan in mice and fruit flies by 11% and 23% 
• Activates sirtuins, which are involved in DNA repair and healthy metabolism 
• Protects against age-related pathology 
• Improves vascular function 
• Suppresses mitochondrial oxidative stress 
• Removes “zombie-like” senescent cells

Trans-resveratrol 500 mg

• Extends lifespan in a vertebrate fish by 59%
• Increases insulin sensitivity and reduces fasting glucose 
• Augments the benefits of weight training on skeletal muscles 
• Works with fisetin to protect against age-related cognitive decline

Spermidine 900 mcg

• Extends longevity in mice by about 10% 
• Improves antitumor immunity 
• Protects against brain aging 
• Induces autophagy 
• Preserves heart health 
• Enhances cognitive function

Quercetin 500 mg

• Extends lifespan in yeast by 60% 
• Enhances the effects of resveratrol 
• Removes senescent cells 
• Improves cardiovascular health 
• Inhibits CD38, which depletes levels of NAD+
• Decreases hair loss 

Citations

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Su, Y., Wang, T., Wu, N., Li, D., Fan, X., Xu, Z., Mishra, S. K., & Yang, M. (2019). Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK. Aging (Albany NY), 11(12), 4183-4197. doi: 10.18632/aging.102045. PMID: 31242135.

Wang Y, Deng P, Liu Y, Wu Y, Chen Y, Guo Y, Zhang S, Zheng X, Zhou L, Liu W, Li Q, Lin W, Qi X, Ou G, Wang C, Yuan Q. Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations. Nat Commun. 2020 Nov 5;11(1):5596. doi: 10.1038/s41467-020-19360-1. 

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Singh, S., Singh, S. K., Yadav, A. K., Pandey, S., Gupta, K., Pandey, H. P., & Srivastava, A. K. (2018). Fisetin, a dietary flavonoid, ameliorates experimental autoimmune arthritis by modulating immune-inflammatory mediators and oxidative stress. Journal of Functional Foods, 40, 552-561. doi: 10.1016/j.jff.2017.11.012

Wood, J., Rogina, B., Lavu, S. et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686–689 (2004). 

Valenzano DR, et al. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 2006; 16:296–300. [PubMed: 16461283]. 

Hoseini et al. The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease. Food & Function 2019; https://doi.org/10.1039/c9fo01075k

Alway et al. Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women. The Journals of Gerontology: Series A 2017; https://doi.org/10.1093/gerona/glx089

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Matsumoto M, Hidaka T, Takeda Y, et al. Spermidine-induced autophagy protects against neuron damage in in vitro and in vivo models of Parkinson's disease. Autophagy.15(7):1129-1149 (2019). doi:10.1080/15548627.2019.1586243

Eisenberg, T., Knauer, H., Schauer, A. et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11, 1305–1314 (2009). https://doi.org/10.1038/ncb1975

Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., ... & Madeo, F. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine, 22(12), 1428-1438 (2016).

Wirth, M., Benson, G., Schwarz, C., Köbe, T., Grittner, U., Schmitz, D., ... & Flöel, A.. The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex. 109: 181-188 (2018). https://doi.org/10.1016/j.cortex.2018.09.014

Arias, N., Macarulla, M.T., Aguirre, L. et al. The combination of resveratrol and quercetin enhances the individual effects of these molecules on triacylglycerol metabolism in white adipose tissue. Eur J Nutr 55, 341–348 (2016). https://doi.org/10.1007/s00394-015-0854-9

Zoico, E., Nori, N., Darra, E., Tebon, M., Rizzatti, V., Policastro, G., De Caro, A., Rossi, A. P., Fantin, F., & Zamboni, M. (2021). Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence. Scientific Reports, 11(1), 1-13. https://doi.org/10.1038/s41598-021-02544-0.

Shasha Yu, Seo Rin Kim, Kai Jiang, Mikolaj Ogrodnik, Xiang Y. Zhu, Christopher M. Ferguson, Tamara Tchkonia, Amir Lerman, James L. Kirkland, Lilach O. Lerman, "Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High-Fat Diet: Role of Angiogenesis", Oxidative Medicine and Cellular Longevity, vol. 2021, Article ID 8875729, 11 pages, 2021. https://doi.org/10.1155/2021/8875729

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